The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). Microwave drying also affected the textural properties of the dried particles with no significant change in the chemical structure.Ī method of preparing tablets called liquisolid technique is currently emerging. The results showed that the crystalline structure, the morphology, and the chemical groups of the dry drug powder are remarkably changed after wet granulation. Powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM) were used to characterize samples before and after wet granulation and drying. Microwave radiation was employed to dry the high moisturized wet granules of naproxen sodium powder. In the present work, a new formulation of naproxen sodium drug was prepared and moisturized to 50 wt% by wet granulation process. Therefore, this study aimed to investigate the impacts of high moisture content due to wet granulation, and drying processes on the textural properties of naproxen sodium powder.
Naproxen sodium is a dipole drug with high affinity towards the water. Naproxen sodium is a common non-steroidal anti-inflammatory drug used as a painkiller or in the therapy of rheumatoid and arthritic diseases. The results suggest that moisture gain and subsequent loss on storage under varying humidity conditions could account for major increases in hardness of compressed tablets in storage. Increased tablet hardnesses resulted in an increase in the disintegration time, although in vitro dissolution of the drug remained unaffected. The magnitude of hardness increase was independent of the hardnesses at the time of compression. After overnight exposure to ambient room conditions, the softened tablets increased in hardness and this increase greatly exceeded the initial hardnesses. After equilibration under high humidities, a decrease in tablet hardness occurred which depended linearly on tablet hardnesses at the time of compression. Hardness, disintegration and dissolution of these tablets did not change on exposure to ambient room conditions. Abstract Interrelationships among moisture, hardness, disintegration and dissolution in compressed tablets were studied by compressing tablets from granulations prepared by the wet granulation process containing low moisture levels.
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